Brain volumetry by voxel-based-morphometry in migraineurs: comparison between groups and clinical correlations

Background
 Migraine was previously interpreted as “benign” disease since the major part of patients were asymptomatic between attacks and brain lesions are absent in primary headaches. Advances structural neuroimaging have changed this point view. Voxel-based-morphometry is an accurate technique to evaluate objectively damage. Our hypothesis that some clinical features migraine, aura attack frequencies, more related volumetric changes migraineurs brains. 
 Objectives
 To compare lobes volumetry migraine (episodic with without aura, chronic migraine) healthy controls. correlations variables variables.
 Methods
 This a cross-sectional study performed 60 female volunteers, aged 18 55 years old, equally allocated into four groups: episodic The sample clinically characterized by following variables: age, number days headache last month, average pain intensity duration calculated from diagnosis MRI performance, use prophylactic drugs for migraine. Volunteers underwent MRI, Free Surfer software used perform studies. Statistical analyses included Mann-Whitney test, Kruskal-Wallis Dunn test Spearmann correlations.
 Results
 No statistically relevant differences found cerebral lobe volumes supratentorial white matter comparison groups. Regarding correlations, age influenced reduction, expected, except parietal lobe, which correlation not important. correlated reduction frontal (p<0.001 / r=-0.531), temporal (p=0.003/r=-0.433), (p=0.004/r=-0.431) lobes; when adjusted age...
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